Published in:
M. Meloun, P. Černohorský: Thermodynamic dissociation constants of isocaine, physostigmine and pilocarpine by regression analysis of potentiometric data, Talanta 52 (2000) 931 - 945.
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Data |
Titration of | Input for ESAB | Output of ESAB | Debye-Huckel law of |
| Data92.xls |
Isocaine Protonation equilibria of isocaine analyzed with ESAB (a) above, left: potentiometric titration curve of isocaine hydrogenchloride with KOH; L0 = 0.0152 mol. dm-3, LT = 1.0777 mol. dm-3, V0 = 10.25 cm3, I = 0.027, t = 25̊C; (b) above, right: plot of residuals; (c) down, left: Bjerrum formation function (ESAB); (d) down, right: distribution diagram of relative presentation of all species of protonation equilibrium. |
Isocaine | Isocaine |
Isocaine Dependence of the mixed dissociation constant pKa of isocaine on the square root of the ionic strength (solid curve) with the 95% confidence bands of prediction for the model proposed (dotted curves), which leads to parameter estimates pKaT = 8.96(1), = 8(3) C and C = 0.50(3) at 25̊C, (ESAB) |
| Physostigmine | Physostigmine | Physostigmine |
Physostigmine Dependence of the mixed dissociation constant pKa of physostigmine on the square root of the ionic strength (solid curve) with the 95% confidence bands of prediction for the model proposed (dotted curves), which leads to parameter estimates pKaT = 8.07(3),= 19(26) C and C = 0.64(3) at 25̊C, (ESAB). |
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| Pilocarpine | Pilocarpine |
Pilocarpine Dependence of the mixed dissociation constant pKa of pilocarpine on the square root of the ionic strength (solid curve) with the 95% confidence bands of prediction for the model proposed (dotted curves), which leads to parameter estimates pKaT = 7.00(1), = 7(1) C and C = 0.53(2) at 25̊C, (ESAB). |
